POEMS syndrome
PARANEOPLASTIC SYNDROME
PEP syndrome; Takatsuki disease; Crow-Fukase syndrome; Poems syndrome; Crow–Fukase syndrome; Polyneuropathy – organomegaly – endocrinopathy – monoclonal gammopathy – skin changes syndrome; Polyneuropathy–organomegaly–endocrinopathy–monoclonal gammopathy–skin changes syndrome; Polyneuropathy-organomegaly-endocrinopathy-monoclonal gammopathy-skin changes syndrome; Polyneuropathy - organomegaly - endocrinopathy - monoclonal gammopathy - skin changes syndrome
POEMS syndrome (also termed osteosclerotic myeloma, Crow–Fukase syndrome, Takatsuki disease, or PEP syndrome) is a rare paraneoplastic syndrome caused by a clone of aberrant plasma cells. The name POEMS is an acronym for some of the disease's major signs and symptoms (polyneuropathy, organomegaly, endocrinopathy, myeloma protein, and skin changes), as is PEP (polyneuropathy, endocrinopathy, plasma cell dyscrasia).